Early Diverging Fungus <i>Mucor circinelloides</i> Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres
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چکیده
منابع مشابه
CENP-A, a conserved centromeric histone within kinetochore chromatin
Studies in several organisms have shown that eukaryotic centromere regions contain proteins involved in chromosome inheritance functions such as centromere structure, heterochromatin assembly and sister chromatid cohesion. Mutation, inhibition, knockout and reciprocal epistasis experiments have revealed functions for many centromere region proteins and their order in the centromere assembly pat...
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CENP-A is a centromere-specific histone H3 variant that is essential for kinetochore formation. Here, we report that the fission yeast Schizosaccharomyces pombe has at least two distinct CENP-A deposition phases across the cell cycle: S and G2. The S phase deposition requires Ams2 GATA factor, which promotes histone gene activation. In Delta ams2, CENP-A fails to retain during S, but it reaccum...
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The histone H3 variant CENP-A is required for epigenetic specification of centromere identity through a loading mechanism independent of DNA sequence. Using multiphoton absorption and DNA cleavage at unique sites by I-SceI endonuclease, we demonstrate that CENP-A is rapidly recruited to double-strand breaks in DNA, along with three components (CENP-N, CENP-T, and CENP-U) associated with CENP-A ...
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15 صفحه اولDNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast
Centromeres are specialized chromatin regions marked by the presence of nucleosomes containing the centromere-specific histone H3 variant CENP-A, which is essential for chromosome segregation. Assembly and disassembly of nucleosomes is intimately linked to DNA topology, and DNA topoisomerases have previously been implicated in the dynamics of canonical H3 nucleosomes. Here we show that Schizosa...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2019
ISSN: 1556-5068
DOI: 10.2139/ssrn.3431419